The Journal of Oral and Maxillofacial Surgery Publishes article evaluating S100A7 biomarker used in Proteocyte AI’s transformative STRATICYTE® test

Toronto, ON; March 20, 2026 – Proteocyte AI announces the Journal of Oral and Maxillofacial Surgery has published a new peer-reviewed study evaluating the clinical value of S100A7, a key biomarker utilized in Proteocyte AI’s innovative STRATICYTE® test. This milestone further reinforces the company’s mission to advance precision risk assessment for patients with oral potentially malignant disorders (OPMDs).

The article, titled “Identifying Malignant Transformation Risk of Dysplastic Oral Lesions Using the S100A7 Biomarker Signature-Based Assay,” provides strong evidence that S100A7 plays a significant role in predicting malignant transformation risk in dysplastic oral lesions. These findings support further investigation of Proteocyte AI’s approach in developing advanced prognostic tools that integrate molecular and digital pathology.

STRATICYTE® is the first clinically validated prognostic test designed to predict an individual’s personalized five-year risk of developing oral cancer. By incorporating the S100A7 biomarker signature into its proprietary algorithm, STRATICYTE® provides clinicians with critical prognostic information that can guide monitoring and treatment strategies beyond conventional histopathologic grading alone.

Results from the newly published study indicate that the biomarker-based risk score (BRS) generated by the STRATICYTE® digital platform may enhance risk stratification, particularly among patients with mild dysplasia. Histopathologic grading has recognized limitations in predicting malignant transformation and does not account for key molecular factors influencing risk. The BRS may help identify patients at lower risk of progression, given its high sensitivity and negative predictive value in this cohort.

The publication adds to the growing body of literature evaluating molecular markers in oral cancer risk assessment.

Dr. Simon Young, DDS, MD, PhD, FACS, Professor, Acting Department Chair, and Director of Research, UT Health Houston and an author of the study, states, “This study highlights the potential role of molecular risk stratification in the management of oral dysplasia. A key strength of the assay in this cohort was its ability to identify patients at low risk of progression, which may help inform surveillance strategies, while higher scores may help flag patients who warrant closer follow-up. Further prospective validation will be important to define how best to integrate this tool into clinical decision-making.”

– 30 –

About Proteocyte

Proteocyte is a personalized medical diagnostics company located in MaRS Centre, Toronto, ON. Proteocyte’s product helps tackle the uncertainty surrounding oral cancer care, one of the most aggressive human cancers. The company’s oral dysplasia predictive test, STRATICYTE™, was developed from a panel of 811 protein biomarkers, leverages over 10 years of R&D, and is positioned to disrupt oral dysplasia and cancer care worldwide.

www.proteocyte.com
Facebook        Twitter      LinkedIn

For more information please contact:
Todd Conrad
Sales & Marketing Advisor
416-779-4806
[email protected]

Forward-Looking Statements
This release may contain forward-looking statements based on current assumptions and forecasts made by Proteocyte management. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, financial situation, development or performance of the company and the estimates given here. The company assumes no liability whatsoever to update these forward-looking statements or to conform them to future events or developments.